genome engineering
NovoHelix has developed precise tools for writing and editing the genome for custom animal models, cell line models, and bacterial strain generation.
- donor/repair vector construction for CRISPR-Cas gene editing
- animal model generation
- CRISPR/Cas-coupled recombineering for industrial Escherichia coli strain engineering
- activity testing of guide RNAs
- targeted epigenetic modification – epigenomic editing
animal models
Animal models are indispensable for biomedical research. NovoHelix designs customized genetic modifications in rodent (mouse, rats) and livestock (pigs, cows, sheep, goats) to generate novel animal models.
- CRISPR-Cas engineered rodent models -
- mouse embryonic stem cell gene targeting
- knockout, knock-in, conditional knockout, safe harbor biomedical modelsgenome editing in large animals
- somatic cell nuclear transfer (SCNT)
- BAC transgenic mouse & rat models
stem cells
NovoHelix can model human disease in a dish by combining two powerful technologies: nuclear reprogramming to pluripotency and gene editing.
- gene edited iPS cells and isogenic controls
- ‘disease-in-a dish’ iPS cell line modeling
- reprogramming to generate iPS cells from samples
- stem cell products
- derivation of new mouse ES cell lines